Marco Colonna, MD

Medical School Department Pathology and Immunology
Research Program Tumor Immunology
Marco Colonna

Researcher Background

Primary Academic Title

Professor of Pathology and Immunology, Section of Immunology and Molecular Pathology, WashU Medicine

Research & Selected Publications

Research Interest

We study the cell surface receptors that activate or inhibit the function of natural killer cells and myeloid cells.

Research Publications

Cell type-specific enhancers regulate IL-22 expression in innate and adaptive type 3 lymphoid cells.
Authors:

Saini A, Hopkins LS, Serna VA, one or more additional authors omitted Colonna M, Oltz EM

Journal & Year:

Nat Commun • 2026

Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth.
Authors:

Mateus-Tique J, Lakshmi A, Singh B, one or more additional authors omitted Colonna M, one or more additional authors omitted Brown BD

Journal & Year:

Cancer Cell • 2026

Divergent ILC3 responses to PDGF-D control mucosal immunity.
Authors:

Fachi JL, de Oliveira S, Trsan T, one or more additional authors omitted Colonna M

Journal & Year:

Sci Immunol • 2026

Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy.
Authors:

Giovannoni F, Strathdee CA, Faust Akl C, one or more additional authors omitted Colonna M, one or more additional authors omitted Quintana FJ

Journal & Year:

Nat Cancer • 2025

The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8+ T cells.
Authors:

Murphy MK, McCullen M, Deffenbaugh JL, one or more additional authors omitted Colonna M, one or more additional authors omitted Egawa T

Journal & Year:

Immunity • 2025

Dual threat: VSIG4⁺ macrophages use IL-11 and VSIG4 to silence T cells.
Authors:

Khantakova D, Colonna M

Journal & Year:

Dev Cell • 2025

Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression.
Authors:

Rea A, Santana-Hernández S, Villanueva J, one or more additional authors omitted Colonna M, one or more additional authors omitted Muntasell A

Journal & Year:

Nat Immunol • 2025

Targeting brain macrophages: NF-κB as a therapeutic gateway in melanoma brain metastasis.
Authors:

Molgora M, Colonna M

Journal & Year:

Cancer Cell • 2025