Nima Mosammaparast, PhD

Medical School Department Pathology and Immunology
Research Program Breast Cancer Research
Nima Mosammaparast

Researcher Background

Primary Academic Title

Professor of Pathology and Immunology, Division of Laboratory and Genomic Medicine, WashU Medicine

Training

  • 2006 - 2009: Resident, Clinical Pathology, Brigham and Women's Hospital, Boston, MA
  • 2009 - 2011: Fellow, Pathology, Brigham and Women's Hospital, Boston, MA

Education

  • 2005: PhD, University of Virginia, Charlottesville, VA
  • 2006: MD, University of Virginia, Charlottesville, VA

Research & Selected Publications

Research Interest

Understanding DNA repair in the chromatin context, and how DNA repair is regulated. Specifically, studying human chromatin modifying enzymes, particularly histone and DNA demethylases that are involved in DNA repair, and their differential regulation in tumor cells.

Research Publications

DNA-damaging chemotherapy reshapes cardiac-resident macrophage composition and function.
Authors:

He R, Kadyrov FF, Koenig AL, one or more additional authors omitted Mosammaparast N, Lavine KJ

Journal & Year:

Sci Immunol • 2026

Human MutLα activates methylpurine DNA glycosylase to induce alkylation damage cytotoxicity.
Authors:

Ashour ME, Krekeler E, Bhowmik MC, one or more additional authors omitted Mosammaparast N

Journal & Year:

bioRxiv • 2025

YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks.
Authors:

Tsao N, Lombardi PM, Park A, one or more additional authors omitted Mosammaparast N

Journal & Year:

Mol Cell • 2025

RNA Damage Responses in Cellular Homeostasis, Genome Stability, and Disease.
Authors:

Zaher HS, Mosammaparast N

Journal & Year:

Annu Rev Pathol • 2025

TCAF1 promotes TRPV2-mediated Ca2+ release in response to cytosolic DNA to protect stressed replication forks.
Authors:

Kong L, Cheng C, Cheruiyot A, one or more additional authors omitted Mosammaparast N, one or more additional authors omitted You Z

Journal & Year:

Nat Commun • 2024

The debranching enzyme Dbr1 regulates lariat turnover and intron splicing.
Authors:

Buerer L, Clark NE, Welch A, one or more additional authors omitted Mosammaparast N, Fairbrother WG

Journal & Year:

Nat Commun • 2024

YTHDC1 cooperates with the THO complex to prevent RNA damage-induced DNA breaks.
Authors:

Tsao N, Olabode J, Rodell R, one or more additional authors omitted Mosammaparast N

Journal & Year:

bioRxiv • 2024

How RNA impacts DNA repair.
Authors:

Tsao N, Ashour ME, Mosammaparast N

Journal & Year:

DNA Repair (Amst) • 2023