Researcher Background
Primary Academic Title
Instructor, Department of Pathology & Immunology, Washington University School of Medicine
Training
- 2007 - 2015: Graduate Student Researcher , Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
- 2016 - 2017: Postdoc , Genomics Research Center, Academia Sinica, Taipei, Taiwan
- 2017 - 2019: Postdoc, Indiana University School of Medicine, Indianapolis, IN
Education
- 2015: PhD, College of Medicine, National Taiwan University, Taipei, Taiwan
Research & Selected Publications
Research Interest
I have a broad interest in genome regulation through various cellular mechanisms and how perturbing any of these mechanisms results in genome instability and cancer development. Previously, I focused on the mechanisms of how nucleotide metabolism contributes to DNA damage repair, and the genomic impacts caused by the unregulated nucleotide metabolism. My current research focuses on how RNA and RNA alkylation impact genome stability. Specifically, we have demonstrated a key role in alkylated RNA in activating DNA damage repair (Tsao et al., Mol Cell 2021). My ongoing work is to understand how various types of RNA damage impact genome integrity, and how these mechanisms determine cancer cells’ susceptibility to established therapeutic agents.