Angela Hirbe, MD, PhD

Medical Oncologist

Angela Hirbe

Appointment Options

Whether you’re seeking a new patient appointment or exploring treatment options and looking for a second opinion, our Siteman care coordinators are ready to assist you.

My Locations

Gary C. Werths Building at Siteman Cancer Center

Gary C. Werths Building at Siteman Cancer Center

On WashU Medicine Campus
4500 Forest Park Avenue, Saint Louis, MO 63108

Expertise & Training

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Angela Hirbe, MD, PhD

2 mins

Washington University medical oncologist, Angela Hirbe, MD, PhD, discusses what patients with sarcomas and rare tumors can expect from their extended care team at Siteman Cancer Center. Learn more about Dr. Hirbe: https://siteman.wustl.edu/doctor/hirbe-angela/

Learn more about the Siteman Approach to Sarcoma/Rare Tumors: https://siteman.wustl.edu/treatment/cancer-types/sarcoma/our-approach/

Learn more about extremity sarcoma treatments: https://siteman.wustl.edu/treatment/cancer-types/sarcoma/musculoskeletal-extremity-treatments/

Learn more about nonextremity sarcoma treatments: https://siteman.wustl.edu/treatment/cancer-types/sarcoma/nonextremity-treatments/

Clinical Expertise

Primary Academic Title

Associate Professor of Medicine and Pediatrics Director, Sarcoma Program Co-Director AYA Sarcoma Program Director, Adult Neurofibromatosis Clinical Program

Board Certification

  • 2012: American Board of Internal Medicine

Training

  • 2009 - 2011: Resident, Internal Medicine, WashU Medicine, St. Louis, MO
  • 2011 - 2012: Chief Resident, Internal Medicine, WashU Medicine, St. Louis, MO
  • 2012 - 2016: Hematology and Oncology Fellow, Postdoctoral Research Fellow, WashU Medicine, St. Louis, MO

Education

  • 2009: MD, PhD, Washington University of Medicine, St. Louis, MO

Research & Selected Publications

Research Interest

Utilize genomic information from human sarcoma to better understand the development and progression of these cancers in order to identify biomarkers and therapeutic targets. The pathogenesis of malignant peripheral nerve sheath tumors (MPNSTs), an aggressive soft tissue sarcoma that occurs at an increased frequency in patients with the Neurofibromatosis Type 1 (NF1) tumor predisposition syndrome.

Research Publications

Neurofibromatosis type 1-plexiform neurofibromas: Integrating treatment across pediatric and adult populations
Authors:

Armstrong AE, Gross AM, Klesse LJ, one or more additional authors omitted Hirbe AC

Journal & Year:

Neuro-oncology | 2026

SARC031: A Phase II Trial of Selumetinib and Sirolimus for Patients with Unresectable or Metastatic Malignant Peripheral Nerve Sheath Tumors (MPNST)
Authors:

Kim A, Ballman KV, Wolters PL, one or more additional authors omitted Hirbe AC, one or more additional authors omitted Widemann BC

Journal & Year:

Clin Cancer Res | 2026

Cabozantinib and temozolomide in patients with unresectable or metastatic leiomyosarcoma and other soft tissue sarcomas: a multicentre, single-arm, lead-in phase 2 trial
Authors:

Monga V, Okuno S, Van Tine B, one or more additional authors omitted Hirbe A, one or more additional authors omitted Agulnik M

Journal & Year:

Lancet Oncol | 2026

Neurogenetic tumor syndromes: The current landscape of workup and treatment
Authors:

Lukas RV, Cannon A, Chittiboina P, one or more additional authors omitted Hirbe AC

Journal & Year:

Neurooncol Pract | 2026

MTA-Cooperative PRMT5 Inhibitors Are Efficacious in MTAP-Deleted Malignant Peripheral Nerve Sheath Tumor Models
Authors:

Zhang X, Borcherding DC, Zhang M, one or more additional authors omitted Hirbe AC

Journal & Year:

Clin Cancer Res | 2025

Integrated Multiclass Driver ctDNA Profiling Enables MPNST Detection and Monitoring in NF1 Patients
Authors:

Jones PA, Bektas AU, Szymanski JJ, one or more additional authors omitted Hirbe AC

Journal & Year:

Res Sq | 2025

Mirdametinib, an FDA-Approved MEK1/2 inhibitor for adult and pediatric NF1-associated plexiform neurofibromas
Authors:

Oztosun G, Armstrong A, Hirbe AC

Journal & Year:

Expert Opin Investig Drugs | 2025

Reply to: Challenges in Assessing Response in Clinical Trials for Neurofibromatosis Type 1 Plexiform Neurofibromas
Authors:

Moertel CL, Hirbe AC, Klesse LJ, one or more additional authors omitted Gershon TR

Journal & Year:

J Clin Oncol | 2025