Timothy Ley, MD

Medical School Department Internal Medicine
Research Program Hematopoietic Development & Malignancy
Timothy Ley

Researcher Background

Primary Academic Title

Lewis T. and Rosalind B. Apple Professor of Oncology in Medicine, Division of Oncology, Section of Stem Cell Biology, WashU Medicine

Training

  • 1978 - 1980: Intern and Resident, Massachusetts General Hospital, Boston, MA
  • 1980 - 1983: Postdoctoral Fellow, Molecular Hematology, National Heart, Blood and Lung Institute, Bethesda, MD
  • 1983 - 1984: Fellow, Hematology/Oncology, Washington University, St. Louis, MO

Education

  • 1978: MD, Washington University, St. Louis, MO

Research & Selected Publications

Research Interest

Regulation of globin gene expression; regulation of gene expression during myelomonocytic development (cathepsin G) and T-Cell activation (Gzm B and H); functions of serine proteases in immune effector cells.

Research Publications

Overexpression of the signaling coordinator GAB2 can play an important role in acute myeloid leukemia progression.
Authors:

Kramer MH, Richardson SN, Li Y, one or more additional authors omitted Ley TJ

Journal & Year:

J Clin Invest • 2025

PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells.
Authors:

Katerndahl CDS, Rogers ORS, Day RB, one or more additional authors omitted Ley TJ

Journal & Year:

Proc Natl Acad Sci USA • 2024

Rapid and accurate remethylation of DNA in Dnmt3a-deficient hematopoietic cells with restoration of DNMT3A activity.
Authors:

Li Y, Abel HJ, Cai M, one or more additional authors omitted Ley TJ

Journal & Year:

Sci Adv • 2024

Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia-initiating CBFB::MYH11 oncofusion protein.
Authors:

Day RB, Hickman JA, Xu Z, one or more additional authors omitted Ley TJ

Journal & Year:

J Clin Invest • 2023