Kenneth Murphy, MD, PhD

Medical School Department Pathology and Immunology
Research Program Tumor Immunology
Kenneth Murphy

Researcher Background

Primary Academic Title

Eugene Opie First Centennial Professor, Pathology & Immunology, Division of Immunology and molecular Pathology, WashU Medicine

Training

  • 1986 - 1990: Postdoctoral Fellow, Washington University, St. Louis, MO

Education

  • 1984: MD/ PhD, Johns Hopkins University, Baltimore, MD

Research & Selected Publications

Research Interest

Regulation of T helper cell differentiation, mechanism of cytokine-induced differentiation and regulation of cytokine gene expression.

Research Publications

Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis.
Authors:

Chen J, Du S, Cheng W, one or more additional authors omitted Murphy KM

Journal & Year:

Immunity • 2026

The Making of a cDC1: Precision Programming of Progenitor Potential.
Authors:

Murphy TL, Murphy KM

Journal & Year:

Immunol Rev • 2026

WDFY4-dependent cross-presentation proceeds via a vacuolar antigen-processing route.
Authors:

Postoak JL, Koch A, Shan S, one or more additional authors omitted Murphy KM

Journal & Year:

Proc Natl Acad Sci USA • 2025

Combined Flt3L and CD40 agonism restores dendritic cell-driven T cell immunity in pancreatic cancer.
Authors:

Hogg GD, Weinstein AG, Kingston NL, one or more additional authors omitted Murphy KM, one or more additional authors omitted DeNardo DG

Journal & Year:

Sci Immunol • 2025

"What's in a name?" Clarifying the identity of RORγt+ antigen-presenting cells.
Authors:

Ou F, Murphy KM

Journal & Year:

J Exp Med • 2025

C/EBPα activates Irf8 expression in myeloid progenitors at the +56-kb enhancer to initiate cDC1 development.
Authors:

Chen J, Liu TT, Ou F, one or more additional authors omitted Murphy KM, Kim S

Journal & Year:

Sci Immunol • 2025

Shared pathway of WDFY4-dependent cross-presentation of immune complexes by cDC1 and cDC2.
Authors:

Jo S, Ohara RA, Theisen DJ, one or more additional authors omitted Murphy KM

Journal & Year:

J Exp Med • 2025

Identification of antigen-presenting cell-T cell interactions driving immune responses to food.
Authors:

Campos Canesso MC, de Castro TBR, Nakandakari-Higa S, one or more additional authors omitted Murphy KM, one or more additional authors omitted Mucida D

Journal & Year:

Science • 2025