Jacqueline Payton, MD, PhD

Medical School Department Pathology and Immunology
Research Program Hematopoietic Development & Malignancy
Jacqueline Payton

Researcher Background

Primary Academic Title

Associate Professor of Pathology and Immunology, Division of Laboratory and Genomic Medicine, WashU Medicine

Training

  • 2004 - 2008: Resident, Pathology, WashU Medicine, St. Louis, MO
  • 2006 - 2007: Clinical Fellow, Internal Medicine, WashU Medicine, St. Louis, MO

Education

  • 2002: PhD, Molecular and Cellular Biology, University of Illinois, Urbana, IL
  • 2004: MD, University of Illinois, Urbana, IL

Research & Selected Publications

Research Interest

Epigenetic alterations and gene regulation in cancer and infection, genomic analyses of cancer, epigenetic mechanisms of cancer progression and therapy resistance, lymphomas and leukemias

Research Publications

Multiomic study of cutaneous T-cell lymphoma reveals single-cell clonal evolution in progression and therapy resistance.
Authors:

Dorando HK, Andrews JM, Khatavkar OU, one or more additional authors omitted Payton JE

Journal & Year:

Blood • 2026

LAIR1 prevents excess inflammatory tissue damage in Staphylococcus aureus skin infection and Cutaneous T-cell Lymphoma.
Authors:

Dorando HK, Mutic EC, Tomaszewski KL, one or more additional authors omitted Payton JE

Journal & Year:

JCI Insight • 2025

Targeting LAIR1-mediated immunosuppression adds a new weapon to our immunotherapy arsenal.
Authors:

Perrin EP, Dorando HK, Payton JE

Journal & Year:

J Clin Invest • 2025

Single Cell Resolution Tracking of Cutaneous T-Cell Lymphoma Reveals Clonal Evolution in Disease Progression.
Authors:

Dorando HK, Andrews JM, Borcherding NC, one or more additional authors omitted Payton JE

Journal & Year:

bioRxiv • 2025

LAIR1 prevents excess inflammatory tissue damage in S. aureus skin infection and Cutaneous T-cell Lymphoma.
Authors:

Dorando HK, Mutic EC, Tomaszewski KL, one or more additional authors omitted Payton JE

Journal & Year:

bioRxiv • 2024

Induced CD8α identifies human NK cells with enhanced proliferative fitness and modulates NK cell activation.
Authors:

Cubitt CC, Wong P, Dorando HK, one or more additional authors omitted Payton JE, Fehniger TA

Journal & Year:

J Clin Invest • 2024

LPS and type I and II interferons have opposing effects on epigenetic regulation of LAIR1 expression in mouse and human macrophages.
Authors:

Dorando HK, Mutic EC, Li JY, one or more additional authors omitted Payton JE

Journal & Year:

J Leukoc Biol • 2024