Matthew Powell, MD

Gynecologic Oncology, Surgeon

Matthew Powell

Appointment Options

Whether you’re seeking a new patient appointment or exploring treatment options and looking for a second opinion, our Siteman care coordinators are ready to assist you.

My Locations

Center for Advanced Medicine

Center for Advanced Medicine

On WashU Medicine Campus
4921 Parkview Place, Saint Louis, MO 63110

Expertise & Training

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Matthew Powell, MD

2 mins

Washington University gynecologic oncologist and surgeon Matthew Powell, MD, discusses what gynecologic cancer patients can expect from their extended care team at Siteman Cancer Center. Learn more about Dr. Powell: https://siteman.wustl.edu/doctor/matthew-powell-md/

Learn more about the Gynecologic Oncology Program at Siteman: https://siteman.wustl.edu/treatment/specialized-programs/gynecologic-oncology/

Almost all cervical cancers are caused by the human papillomavirus (HPV). Here's what you need to know about the link between HPV and cervical cancer: https://siteman.wustl.edu/facts-about-hpv-cervical-cancer/

Symptoms of ovarian cancer can be easy to miss. Learn about what signs to look out for: https://siteman.wustl.edu/subtle-signs-of-ovarian-cancer-women-should-look-out-for/

Endometrial cancer is the 4th most common cancer in women in the U.S., but it's highly curable when caught early. Learn more about the risk factors, symptoms and screening: https://siteman.wustl.edu/endometrial-cancer-symptoms/

Clinical Expertise

Primary Academic Title

Ira C. and Judith Gall Professor of Obstetrics and Gynecology, Division of Gynecologic Oncology, WashU Medicine

Board Certification

  • 1: American Board of Obstetrics and Gynecology, Obstetrics and Gynecology
  • 1: American Board of Obstetrics and Gynecology, Gynecologic Oncology

Training

  • 2002: Fellowship, Gynecologic Oncology, Washington University School of Medicine, St. Louis, Missouri
  • 1999: Resident, Obstetrics and Gynecology, Ohio State University Hospital and Clinics, Columbus, Ohio
  • 1989: Research Fellow, University of Washington, Northwest College and University Association for Science, Richland, Washington

Education

  • 1995: MD, Michigan State University, East Lansing, MI

Research & Selected Publications

Research Interest

My clinical research interests are primarily in the diagnosis and treatment of uterine and ovarian cancers with chemotherapy and radiation. I am also studying pharmacologic treatment of preinvasive abnormalities of the uterine cervix in an effort to help some patients avoid surgery and loss of fertility. My laboratory research focuses on endometrial cancer etiology and tumor marker development.

Research Publications

Repositioning GLP-1 Receptor Agonists in Endometrial Cancer: Molecular Rationale, Preclinical Insights, and Translational Opportunities
Authors:

Podder V, Coleman RL, Hagemann AR, one or more additional authors omitted Powell MA, one or more additional authors omitted Slomovitz BM

Journal & Year:

Clin Cancer Res | 2026

Multiomic Characterization of Pre- and Post-Neoadjuvant Chemotherapy-Treated Ovarian Cancer Reveals Mediators of Tumorigenesis and Chemotherapy Response
Authors:

Valentine MC, Mullen MM, Kotnik EN, Powell MA, one or more additional authors omitted Fuh KC

Journal & Year:

Cancer Res | 2025

Phospho-RPA2 predicts response to platinum and PARP inhibitors in homologous recombination-proficient ovarian cancer
Authors:

Schab A, Compadre A, Drexler R, one or more additional authors omitted Powell M, one or more additional authors omitted Mullen MM

Journal & Year:

J Clin Invest | 2025

Pembrolizumab plus chemotherapy in advanced or recurrent endometrial cancer: overall survival and exploratory analyses of the NRG GY018 phase 3 randomized trial
Authors:

Eskander RN, Sill MW, Beffa L, one or more additional authors omitted Powell MA, Aghajanian C

Journal & Year:

Nat Med | 2025

Long-Term Follow-Up and Overall Survival in NRG258, a Randomized Phase III Trial of Chemoradiation Versus Chemotherapy for Locally Advanced Endometrial Carcinoma
Authors:

Matei DE, Enserro DM, Randall ME, one or more additional authors omitted Powell MA, one or more additional authors omitted Miller DS

Journal & Year:

J Clin Oncol | 2025

A plain language summary publication of patients' survival with endometrial cancer treated with dostarlimab plus carboplatin-paclitaxel
Authors:

Powell MA, Bjørge L, Willmott L, one or more additional authors omitted Mirza MR

Journal & Year:

Ther Adv Med Oncol | 2025

Efficacy and safety of dostarlimab in combination with chemotherapy in patients with dMMR/MSI-H primary advanced or recurrent endometrial cancer in a phase 3, randomized, placebo-c…
Authors:

Powell MA, Cibula D, O'Malley DM, one or more additional authors omitted Mirza MR

Journal & Year:

Gynecol Oncol | 2025

A Plain Language Summary of "Dostarlimab for primary advanced or recurrent endometrial cancer"
Authors:

Mirza MR, Chase DM, Slomovitz BM, one or more additional authors omitted Powell MA

Journal & Year:

Future Oncol | 2025