Kooresh Shoghi, PhD

Medical School Department Radiology
Research Program Oncologic Imaging
Kooresh Shoghi

Researcher Background

Primary Academic Title

Professor of Radiology, WashU Medicine

Education

  • 2000: MS, Biomathematics, University of California, Los Angeles, CA
  • 2005: PhD, Biomathematics, University of California, Los Angeles, CA

Research & Selected Publications

Research Interest

Computational biology at the interface with molecular imaging. We have developed state-of-the-art image quantification and processing algorithms for quantification of PET images with applications to metabolism and cellular proliferation, among others. We use computational biology to facilitate the understanding of molecular imaging and therapeutic targets in health and disease.

Research Publications

Noise-aware system generative model (NASGM): positron emission tomography (PET) image simulation framework with observer validation studies.
Authors:

Li S, Dutta K, Pal D, Shoghi KI

Journal & Year:

Med Phys • 2025

Corr-A-Net: Interpretable Attention-Based Correlated Feature Learning framework for predicting of HER2 Score in Breast Cancer from H&E Images.
Authors:

Dutta K, Pal D, Li S, Shyam C, Shoghi KI

Journal & Year:

medRxiv • 2025

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages.
Authors:

Iglesia MD, Jayasinghe RG, Chen S, one or more additional authors omitted Shoghi KI, one or more additional authors omitted Ding L

Journal & Year:

Nat Cancer • 2024

Tumour evolution and microenvironment interactions in 2D and 3D space.
Authors:

Mo CK, Liu J, Chen S, one or more additional authors omitted Shoghi KI, one or more additional authors omitted Ding L

Journal & Year:

Nature • 2024

FAST (fast analytical simulator of tracer)-PET: an accurate and efficient PET analytical simulation tool.
Authors:

Li S, Hamdi M, Dutta K, one or more additional authors omitted Shoghi KI

Journal & Year:

Phys Med Biol • 2024

Deep learning generation of preclinical positron emission tomography (PET) images from low-count PET with task-based performance assessment.
Authors:

Dutta K, Laforest R, Luo J, Jha AK, Shoghi KI

Journal & Year:

Med Phys • 2024

Discovery and Targeting of a Noncanonical Mechanism of Sarcoma Resistance to ADI-PEG20 Mediated by the Microenvironment.
Authors:

Rogers LC, Kremer JC, Brashears CB, one or more additional authors omitted Shoghi KI, one or more additional authors omitted Van Tine BA

Journal & Year:

Clin Cancer Res • 2023