David Spencer, PhD

Medical School Department Internal Medicine
Research Program Hematopoietic Development & Malignancy
David Spencer

Researcher Background

Primary Academic Title

Associate Professor, Section of Stem Cell Biology, Division of Oncology, WashU Medicine

Training

  • 2010 - 2011: Chief Resident, Clinical Pathology, Barnes-Jewish Hospital, St. Louis, MO

Education

  • 2008: PhD, University of Washington, Seattle, WA
  • 2010: MD, University of Washington, Seattle, WA

Research & Selected Publications

Research Interest

My research program studies epigenetic gene regulation in cancer, with a specific emphasis on understanding how mutations in acute myeloid leukemia (AML) perturb the epigenome to alter gene expression and cause leukemia.

Research Publications

Evaluation of Long-Read Genome Sequencing for Genomic Profiling of Myeloid Cancers.
Authors:

Abel HJ, Mahgoub M, Davarapalli N, one or more additional authors omitted Spencer DH

Journal & Year:

J Mol Diagn • 2025

Intermediately Methylated Regions in Normal Cells Are Epimutation Hotspots in Cancer.
Authors:

Mahgoub M, Abel H, Davarapalli N, one or more additional authors omitted Spencer DH

Journal & Year:

bioRxiv • 2025

Missense Mutations in Myc Box I Influence Nucleocytoplasmic Transport to Promote Leukemogenesis.
Authors:

Arthur NBJ, Christensen KA, Mannino K, one or more additional authors omitted Spencer DH, one or more additional authors omitted Ferraro F

Journal & Year:

Clin Cancer Res • 2024