Gregory Zipfel, MD

Brain Tumor Specialist, Neurosurgeon

Gregory Zipfel

Appointment Options

Whether you’re seeking a new patient appointment or exploring treatment options and looking for a second opinion, our Siteman care coordinators are ready to assist you.

My Locations

Gary C. Werths Building at Siteman Cancer Center

Gary C. Werths Building at Siteman Cancer Center

On WashU Medicine Campus
4500 Forest Park Avenue, Saint Louis, MO 63108
Center for Advanced Medicine

Center for Advanced Medicine

On WashU Medicine Campus
4921 Parkview Place, Saint Louis, MO 63110
Parkview Tower at Barnes-Jewish Hospital

Parkview Tower at Barnes-Jewish Hospital

On WashU Medicine Campus
1 Parkview Place, Saint Louis, MO 63110
S. Lee Kling Proton Therapy Center

S. Lee Kling Proton Therapy Center

On WashU Medicine Campus
224 Euclid Ave. , Saint Louis, MO 63110
Siteman Kids at St. Louis Children’s Hospital

Siteman Kids at St. Louis Children’s Hospital

On WashU Medicine Campus
1 Children's Place, St. Louis, MO 63110

Expertise & Training

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Gregory Zipfel, MD

3 mins

Washington University neurosurgeon Gregory Zipfel, MD, discusses what brain cancer patients can expect from their extended care team at Siteman Cancer Center. Learn more about Dr. Zipfel: https://siteman.wustl.edu/doctor/zipfel-gregory/

Explore the Brain Tumor Center at Siteman: https://siteman.wustl.edu/treatment/cancer-types/brain-tumor-center/

Learn more about how Siteman personalizes brain tumor treatment: https://siteman.wustl.edu/personalized-brain-tumor-treatment/

Learn more about how Siteman's innovations in brain tumor surgery are advancing treatment: https://siteman.wustl.edu/innovations-brain-tumor-surgery/

For me [neurosurgery] felt like an opportunity to really help people who in some ways are really looking for hope, looking for help in something that hits in the heart of who they are.

Gregory Zipfel, MD

Clinical Expertise

Primary Academic Title

Ralph G. Dacey Distinguished Professor of Neurological Surgery and Chairman of Neurological Surgery, Washington University School of Medicine

Board Certification

  • 2008: American Board of Neurological Surgery

Training

  • 1996 - 1996: Intern, General Surgery, University of Florida, Gainesville, FL
  • 1996 - 2003: Resident and Chief Resident, University of Florida, Gainesville, FL
  • 1998 - 2000: Research Fellow, WashU Medicine, St. Louis, MO
  • 2003 - 2004: Fellow, Cerebrovascular and Skull Base Surgery, University of Miami, Miami, FL

Education

  • 1995: MD, Northwestern University, Chicago, IL

Research & Selected Publications

Research Interests

Benign and malignant brain tumors, particularly complex tumors of the skull base, including meningioma, schwannoma, acoustic neuroma, carniofacial tumors and chordoma/chondrosarcoma.

Research Publications

Adjuvant personalized multivalent neoantigen DNA vaccination for MGMT unmethylated glioblastoma: a phase 1 trial
Authors:

Garfinkle EAR, Perales-Linares R, Gimple RC, one or more additional authors omitted Zipfel GJ, one or more additional authors omitted Johanns TM

Journal & Year:

Nat Cancer | 2026

Postoperative fluid restriction to prevent delayed hyponatremia after endoscopic transsphenoidal surgery
Authors:

Klaassen D, Mok S, Hwang JY, one or more additional authors omitted Zipfel GJ, one or more additional authors omitted Silverstein JM

Journal & Year:

Neuro-oncology | 2025

Integrating Multisector Molecular Characterization into Personalized Peptide Vaccine Design for Patients with Newly Diagnosed Glioblastoma
Authors:

Johanns TM, Garfinkle EAR, Miller KE, one or more additional authors omitted Zipfel GJ, one or more additional authors omitted Dunn GP

Journal & Year:

Clin Cancer Res | 2024

Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state
Authors:

Barrett TF, Patel B, Khan SM, one or more additional authors omitted Zipfel GJ, one or more additional authors omitted Kim AH

Journal & Year:

Nat Commun | 2024