Kiran Mahajan, PhD

Medical School Department Surgery
Research Program Solid Tumor Therapeutics
Kiran Mahajan

Researcher Background

Primary Academic Title

Associate Professor of Surgery Chief, Section of Surgical Therapeutics Division of Surgical Sciences Division of Urologic Surgery, WashU Medicine

Training

  • 1998 - 2004: Postgraduate Training, Lineberger Comprehensive Cancer Center, Chapel Hill, NC

Education

  • 1998: PhD, Indian Institute of Science, Bangalore, India

Research & Selected Publications

Research Interest

Employing human prostate organoid model systems and immunocompetent Genetically Engineered Mouse models (GEM) models of prostate cancer to develop and characterize novel small molecule inhibitors to uncover their therapeutic potential and mechanism of action for targeting clinically significant prostate cancers. A second major interest of the lab, is the epigenetic regulation of DNA damage signaling pathways in prostate and breast cancers.

Research Publications

Prostate-Specific Membrane Antigen-Targeted Imaging and Its Correlation with HOXB13 Expression.
Authors:

Angappulige DH, Barashi NS, Pickersgill N, one or more additional authors omitted Mahajan K

Journal & Year:

J Nucl Med • 2024

SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis.
Authors:

Chouhan S, Sridaran D, Weimholt C, one or more additional authors omitted Mahajan K, Mahajan NP

Journal & Year:

Nat Commun • 2024

Amino Terminal Acetylation of HOXB13 Regulates the DNA Damage Response in Prostate Cancer.
Authors:

Nguyen DT, Mahajan U, Angappulige DH, one or more additional authors omitted Mahajan K

Journal & Year:

Cancers (Basel) • 2024

Epigenetic underpinnings of tumor-immune dynamics in prostate cancer immune suppression.
Authors:

Angappulige DH, Mahajan NP, Mahajan K

Journal & Year:

Trends Cancer • 2024

Symptomatic Benign Prostatic Hyperplasia with Suppressed Epigenetic Regulator HOXB13 Shows a Lower Incidence of Prostate Cancer Development.
Authors:

Barashi NS, Li T, Angappulige DH, one or more additional authors omitted Mahajan K

Journal & Year:

Cancers (Basel) • 2024

Prostate cancer immunotherapy: Improving clinical outcomes with a multi-pronged approach.
Authors:

Sridaran D, Bradshaw E, DeSelm C, one or more additional authors omitted Mahajan K, Mahajan NP

Journal & Year:

Cell Rep Med • 2023