Benjamin Garcia, PhD

Medical School Department Chemistry
Research Program Mechanisms of Cancer Biology Program
Benjamin Garcia

Researcher Background

Primary Academic Title

Professor and Head of the Department of Biochemistry and Molecular Biophysics, WashU Medicine

Training

  • 2005 - 2008: Postdoctoral Fellow, Genomic Biology, University of Illinois, Urbana-Champaign, IL

Education

  • 2005: PhD, Chemistry, University of Virginia, Charlottesville, VA

Research & Selected Publications

Research Interest

Developing methodologies for the analysis of protein post-translational modifications (PTMs) and modified proteomes, with a particular interest in understanding the roles of protein PTMs during cancer pathogenesis, neurodegeneration and cell differentiation

Research Publications

NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers.
Authors:

Jeong J, Hausmann S, Dong H, one or more additional authors omitted Garcia BA, one or more additional authors omitted Gozani O

Journal & Year:

Nature • 2026

Mass Spectrometry Analysis of Nucleic Acid Modifications: From Beginning to Future.
Authors:

Xie Y, Brás-Costa C, Lin Z, Garcia BA

Journal & Year:

Mass Spectrom Rev • 2026

An unbiased proteomic platform for ATE1-based arginylation profiling.
Authors:

Lin Z, Xie Y, Gongora J, one or more additional authors omitted Garcia BA

Journal & Year:

Nat Chem Biol • 2025

The mitotic STAG3-cohesin complex shapes male germline nucleome.
Authors:

Nagano M, Hu B, Ogata K, one or more additional authors omitted Garcia BA, one or more additional authors omitted Saitou M

Journal & Year:

Nat Struct Mol Biol • 2025

Chromatin profiling identifies putative dual roles for H3K27me3 in regulating cell type-specific genes and transposable elements in choanoflagellates.
Authors:

Gahan JM, Helfrich LW, Wetzel LA, one or more additional authors omitted Garcia BA, one or more additional authors omitted Booth DS

Journal & Year:

Nat Commun • 2025

KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia.
Authors:

Michmerhuizen NL, Heikamp EB, Iacobucci I, one or more additional authors omitted Garcia BA, one or more additional authors omitted Mullighan CG

Journal & Year:

Cancer Discov • 2025

A needed nomenclature for nucleosomes.
Authors:

Keogh MC, Almouzni G, Andrews AJ, one or more additional authors omitted Garcia BA, one or more additional authors omitted Young NL

Journal & Year:

Mol Cell • 2025

Development and application of GlycanDIA workflow for glycomic analysis.
Authors:

Xie Y, Liu X, Yi L, one or more additional authors omitted Garcia BA

Journal & Year:

Nat Commun • 2025