Sytse Piersma, PhD

Medical School Department Internal Medicine
Research Program Tumor Immunology
Sytse Piersma

Researcher Background

Primary Academic Title

Instructor of Medicine, Division of Rheumatology, WashU Medicine

Training

  • 2009 - 2011: Postdoctoral Fellow, Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands
  • 2011 - 2013: Postdoctoral Fellow, Rheumatology, WashU Medicine, St. Louis, MO
  • 2013 - 2014: Researcher, Oncology, Leiden University Medical Center, Leiden, Netherlands
  • 2014: Postdoctoral Fellow, Rheumatology, WashU Medicine, St. Louis, MO

Education

  • 2010: PhD, Clinical Oncology and Immunohematology, University Medical Center Utrecht, Utrecht, Netherlands

Research & Selected Publications

Research Interest

Improving immunotherapy through studying natural killer (NK) cells

Research Publications

Unleashing NK cells for cancer immunotherapy in lung cancer: biologic challenges and clinical advances.
Authors:

McLaughlin Q, Sojka DK, Kennedy K, Piersma SJ , Sethakorn N

Journal & Year:

J Exp Clin Cancer Res • 2025

Shared pathway of WDFY4-dependent cross-presentation of immune complexes by cDC1 and cDC2.
Authors:

Jo S, Ohara RA, Theisen DJ, one or more additional authors omitted Piersma SJ, one or more additional authors omitted Murphy KM

Journal & Year:

J Exp Med • 2025

Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions.
Authors:

Piersma SJ, Li S, Wong P, one or more additional authors omitted Yokoyama WM

Journal & Year:

Elife • 2025

Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions.
Authors:

Piersma SJ, Li S, Wong P, one or more additional authors omitted Yokoyama WM

Journal & Year:

bioRxiv • 2024

Tissue-specific features of innate lymphoid cells in antiviral defense.
Authors:

Piersma SJ

Journal & Year:

Cell Mol Immunol • 2024

Cis-regulatory evolution of the recently expanded Ly49 gene family.
Authors:

Fan C, Xing X, Murphy SJH, one or more additional authors omitted Piersma SJ, one or more additional authors omitted Wang T

Journal & Year:

Nat Commun • 2024

NK cell expansion requires HuR and mediates control of solid tumors and long-term virus infection.
Authors:

Piersma SJ, Bangru S, Yoon J, one or more additional authors omitted Yokoyama WM

Journal & Year:

J Exp Med • 2023