Reyka Jayasinghe, PhD

Medical School Department Internal Medicine
Research Program Hematopoietic Development & Malignancy
Reyka Jayasinghe

Researcher Background

Primary Academic Title

Assistant Professor, Department of Internal Medicine, WashU Medicine

Training

  • 2018 - 2020: Postdoctoral Research Associate, Washington University School of Medicine, St. Louis, MO

Education

  • 2013: BS, San Francisco State University, CA
  • 2018: PhD, Washington University School of Medicine, St. Louis, MO

Research & Selected Publications

Research Interest

The long-term goal of my research is to use single-cell and spatial technologies to understand the gene expression dynamics in tumor and immune cells during cancer initiation, treatment, and disease progression, with a particular focus on prostate and pancreatic cancer and blood cancers including multiple myeloma. Further, our lab is actively sequencing patients affected by various cancer types in underrepresented groups to better characterize the genomic and transcriptional cancer landscape of understudied ethnic groups. In the long run, we hope to both address cancer disparities and strengthen our understandings about the interplay between cancer and pre-cancerous lesions and the tumor microenvironment during disease progression.

Research Publications

Longitudinal Profiling of Tumor and Immune Compartments Uncovers Patterns of Dysregulation and Associations with Response in Multiple Myeloma.
Authors:

Ohlstrom DJ, Pilcher WC, Michaud ME, one or more additional authors omitted Jayasinghe RG, one or more additional authors omitted Bhasin MK

Journal & Year:

Blood Cancer Discov • 2026

A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma.
Authors:

Pilcher WC, Yao L, Gonzalez-Kozlova E, one or more additional authors omitted Jayasinghe RG, one or more additional authors omitted Bhasin M

Journal & Year:

Nat Cancer • 2026

Combined Flt3L and CD40 agonism restores dendritic cell-driven T cell immunity in pancreatic cancer.
Authors:

Hogg GD, Weinstein AG, Kingston NL, one or more additional authors omitted Jayasinghe RG, one or more additional authors omitted DeNardo DG

Journal & Year:

Sci Immunol • 2025

Single-cell transcriptomic profiling reveals diversity in human iNKT cells across hematologic tissues.
Authors:

Jayasinghe RG, Hollingsworth D, Schedler NC, one or more additional authors omitted Mavers M

Journal & Year:

Cell Rep • 2025

Itacitinib for prevention of graft-versus-host disease and cytokine release syndrome in haploidentical transplantation.
Authors:

Abboud R, Schroeder MA, Rettig MP, Jayasinghe RG, one or more additional authors omitted DiPersio JF

Journal & Year:

Blood • 2025

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages.
Authors:

Iglesia MD, Jayasinghe RG, Chen S, one or more additional authors omitted Ding L

Journal & Year:

Nat Cancer • 2024

Tumour evolution and microenvironment interactions in 2D and 3D space.
Authors:

Mo CK, Liu J, Chen S, one or more additional authors omitted Jayasinghe RG, one or more additional authors omitted Ding L

Journal & Year:

Nature • 2024

Multi-scale signaling and tumor evolution in high-grade gliomas.
Authors:

Liu J, Cao S, Imbach KJ, one or more additional authors omitted Jayasinghe RG, one or more additional authors omitted Ding L

Journal & Year:

Cancer Cell • 2024