Yin Cao, ScD, MPH

Academic Department Community Health, Surgery
Research Program Prevention and Control
Yin Cao

Researcher Background

Primary Academic Title

Professor of Surgery, Division of Public Health Sciences, WashU Medicine

Training

  • 2013 - 2015: Postdoctoral Fellow, Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA

Education

  • 2013: ScD, Epidemiology, Harvard School of Public Health, Boston, MA
  • 2009: MPH, Epidemiology, Columbia University, New York, NY

Research & Select Publications

Research Interest

Cao’s research aims to advance how we understand the emergence of cancer at younger ages, with a primary focus on colorectal and other gastrointestinal cancers. Her lab is committed to uncovering when, where, and how early-onset cancers begin, and how they can be intercepted. By constructing a multidimensional framework across exposures, tissue types, life stages, and populations, the lab investigates both external and internal drivers to uncover causal pathways of cancer risk and progression in younger individuals. Cao lab is deeply committed to advancing team science to address complex challenges in cancer and public health. She co-leads the Cancer Grand Challenges Team PROSPECT, Biobank and Big Data Core at the WashU Digestive Diseases Research Core Center, and WashU Transcend Initiative on Air Quality and Health.

Research Publications

Parental obesity and risk of metabolic dysfunction associated steatotic liver disease in adult offspring: UK birth cohort study.
Authors:

Tica S, Luo C, Ren D, one or more additional authors omitted Cao Y

Journal & Year:

Gut • 2026

Germline alterations in patients with lung cancer.
Authors:

Govindan R, Navo K, Huang M, one or more additional authors omitted Cao Y

Journal & Year:

Ann Oncol • 2026

Toward AI-Powered Cancer Etiology Research.
Authors:

Ji M, Zhang L, Zitnik M, one or more additional authors omitted Cao Y

Journal & Year:

Cancer Discov • 2026

Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers.
Authors:

Shi M, Patti GJ, Gunter MJ, one or more additional authors omitted Cao Y

Journal & Year:

Cell • 2026

Approach Toward Early Detection and Prevention of Early-Onset Colorectal Cancer.
Authors:

Fritz CDL, George M, Carethers JM, Cao Y

Journal & Year:

Annu Rev Med • 2026

Ultraprocessed Food Consumption and Risk of Early-Onset Colorectal Cancer Precursors Among Women.
Authors:

Wang C, Du M, Kim H, one or more additional authors omitted Cao Y, Chan AT

Journal & Year:

JAMA Oncol • 2026

Early-onset colorectal cancer as an emerging disease of metabolic dysregulation.
Authors:

Du M, Drew DA, Goncalves MD, Cao Y , Chan AT

Journal & Year:

Nat Rev Endocrinol • 2025

Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy.
Authors:

Liu J, Tran D, Xue L, one or more additional authors omitted Cao Y, one or more additional authors omitted Bolton KL

Journal & Year:

Nat Genet • 2025

Integration of Germline and Somatic Variation Improves Chronic Lymphocytic Leukemia Risk Stratification.
Authors:

Hubbard AK, Brown DW, Liu J, one or more additional authors omitted Cao Y, one or more additional authors omitted Machiela MJ

Journal & Year:

Cancer Res • 2025

The diverse roles of the circadian clock in cancer.
Authors:

Fortin BM, Mahieu AL, Fellows RC, one or more additional authors omitted Cao Y, one or more additional authors omitted Masri S

Journal & Year:

Nat Cancer • 2025

Colorectal cancer incidence trends in younger versus older adults: an analysis of population-based cancer registry data.
Authors:

Sung H, Siegel RL, Laversanne M, one or more additional authors omitted Cao Y, one or more additional authors omitted Jemal A

Journal & Year:

Lancet Oncol • 2025

Aspirin Use and Incidence of Colorectal Cancer According to Lifestyle Risk.
Authors:

Sikavi DR, Wang K, Ma W, one or more additional authors omitted Cao Y, one or more additional authors omitted Chan AT

Journal & Year:

JAMA Oncol • 2024

Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism.
Authors:

Zhang Y, Higgins CB, Tica S, one or more additional authors omitted Cao Y, DeBosch BJ

Journal & Year:

Cell Metab • 2024

Plasma Proteomic Signature Predicts Myeloid Neoplasm Risk.
Authors:

Tran D, Beeler JS, Liu J, one or more additional authors omitted Cao Y, Bolton KL

Journal & Year:

Clin Cancer Res • 2024

Being Breastfed in Infancy and Risk of Colorectal Cancer and Precursor Lesions.
Authors:

Yuan C, Wang QL, Kim H, one or more additional authors omitted Cao Y, one or more additional authors omitted Ng K

Journal & Year:

Clin Gastroenterol Hepatol • 2024