Researcher Background
Primary Academic Title
Assistant Professor, Department of Medicine, Division of Oncology, WashU Medicine
Training
- 2010 - 2011: Research and Development Engineering Intern, FLIR Systems (ICx Agentase), Pittsburgh, PA
- 2014 - 2022: Postdoctoral Fellow, Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, PA
Education
- 2014: PhD, University of Oklahoma, Norman, OK
Research & Select Publications
Research Interest
The external environment and normal cellular processes can cause damage to DNA. Breaks to both strands of DNA are a significant threat to genome integrity and lead to a complex cellular response comprised of multiple DNA repair pathway options. Defects or inappropriate use of a repair mechanism impacts genome stability, cell survival, organismal development, and disease progression. Despite the consequential decision-making that occurs with each break, how a cell determines the appropriate repair mechanism remains poorly understood. Our laboratory investigates the signaling mechanisms that regulate double-strand DNA break repair to better understand cancer development and to design improved therapeutic approaches.
Research Publications