Sidharth Puram, MD, PhD

Head and Neck Surgeon

Sidharth Puram

Appointment Options

Whether you’re seeking a new patient appointment or exploring treatment options and looking for a second opinion, our Siteman care coordinators are ready to assist you.

My Locations

Gary C. Werths Building at Siteman Cancer Center

Gary C. Werths Building at Siteman Cancer Center

On WashU Medicine Campus
4500 Forest Park Avenue, Saint Louis, MO 63108

Expertise & Training

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Dr. Sidharth Puram, MD

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Dr. Sidharth Puram, MD Associate Professor of Otolaryngology, Division of Head and Neck Surgery, Washington University School of Medicine at Siteman Cancer Center

Clinical Expertise

  • Head and Neck Surgery

Primary Academic Title

Professor of Otolaryngology and Genetics, Chief, Division of Head and Neck Surgery, Director, Head and Neck Tumor Center, WashU Medicine

Board Certification

  • 2019: American Board of Otolaryngology (in review)

Training

  • 2013 - 2014: Intern, General Surgery, Massachusetts General Hospital, Boston, MA
  • 2014 - 2017: Resident, Otolaryngology, Harvard Combined Program in Otolaryngology, Boston, MA
  • 2017 - 2018: Chief Resident, Otolaryngology, Harvard Combined Program in Otolaryngology, Boston, MA
  • 2018 - 2019: Fellow, Head and Neck Oncology, Ohio State University, Columbus, OH

Education

  • 2011: PhD, Harvard Medical School, Boston, MA
  • 2013: MD, Harvard Medical School, Boston, MA

Research & Select Publications

Research Interest

Tumor heterogeneity in head and neck cancer and its implications for prognosis, treatment response, and underlying biology, head and neck squamous carcinoma, additional interests include salivary malignancies.

Research Publications

Postoperative Lymph Is a Proximal Source of ctDNA for Detection of Recurrence in HPV-Independent Head and Neck Cancer
Authors:

Lazare S, Gu Z, Earland N, one or more additional authors omitted Puram S, one or more additional authors omitted Zevallos JP

Journal & Year:

Clin Cancer Res | 2026

Scalable transcription factor mapping uncovers the regulatory dynamics of natural and synthetic transcription factors in human T cell states
Authors:

Mullins RDZ, Zaretsky J, Stoller E, one or more additional authors omitted Puram SV

Journal & Year:

bioRxiv | 2025

Management of HPV+ head and neck squamous cell carcinoma with unknown primary in the era of treatment de-escalation
Authors:

Barrett TF, Apicelli AJ, Ramadan S, one or more additional authors omitted Puram SV

Journal & Year:

Oral Oncol | 2025

Establishing an integrated approach to head and neck cancer treatment and prevention: The Robert Ebert and Greg Stubblefield Head and Neck Tumor Center Model
Authors:

Ashok A, Dimitri S, Plonowska-Hirschfeld K, one or more additional authors omitted Puram SV

Journal & Year:

Oral Oncol | 2025

Comparison Between Intraoperative Frozen Sections and Final Tumor Specimen Histopathology in HPV-Related OPSCC-Reply
Authors:

Puram SV, Jackson RS, Ramadan S

Journal & Year:

JAMA Otolaryngol Head Neck Surg | 2025

The Curated Cancer Cell Atlas provides a comprehensive characterization of tumors at single-cell resolution
Authors:

Tyler M, Gavish A, Barbolin C, one or more additional authors omitted Puram SV, Tirosh I

Journal & Year:

Nat Cancer | 2025

Immunotherapeutic strategies in head and neck cancer: challenges and opportunities
Authors:

Liu X, Harbison RA, Varvares MA, Puram SV , Peng G

Journal & Year:

J Clin Invest | 2025

Use of Intraoperative Frozen Section to Assess Surgical Margins in HPV-Related Oropharyngeal Carcinoma
Authors:

Ramadan S, Bellas A, Al-Qurayshi Z, one or more additional authors omitted Puram SV

Journal & Year:

JAMA Otolaryngol Head Neck Surg | 2025

Tumor extracellular vesicle-derived PD-L1 promotes T cell senescence through lipid metabolism reprogramming
Authors:

Ma F, Liu X, Zhang Y, one or more additional authors omitted Puram SV, one or more additional authors omitted Peng G

Journal & Year:

Sci Transl Med | 2025

Multidimensional profiling of human T cells reveals high CD38 expression, marking recent thymic emigrants and age-related naive T cell remodeling
Authors:

Bohacova P, Terekhova M, Tsurinov P, one or more additional authors omitted Puram SV, one or more additional authors omitted Artyomov MN

Journal & Year:

Immunity | 2024

Tumour evolution and microenvironment interactions in 2D and 3D space
Authors:

Mo CK, Liu J, Chen S, one or more additional authors omitted Puram SV, one or more additional authors omitted Ding L

Journal & Year:

Nature | 2024

A hybrid epithelial/mesenchymal state in head and neck cancer: A biomarker for survival with differential prognosis by self-reported race
Authors:

Mazul AL, Barrett TF, Colditz G, one or more additional authors omitted Puram SV

Journal & Year:

Med (N Y) | 2024

Blocking senescence and tolerogenic function of dendritic cells induced by γδ Treg cells enhances tumor-specific immunity for cancer immunotherapy
Authors:

Si F, Liu X, Tao Y, one or more additional authors omitted Puram SV, Peng G

Journal & Year:

J Immunother Cancer | 2024

Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state
Authors:

Barrett TF, Patel B, Khan SM, one or more additional authors omitted Puram SV, Kim AH

Journal & Year:

Nat Commun | 2024

Patient Navigation for Timely, Guideline-Adherent Adjuvant Therapy for Head and Neck Cancer: A National Landscape Analysis
Authors:

Graboyes EM, Chappell M, Duckett KA, one or more additional authors omitted Puram SV, one or more additional authors omitted Calhoun E

Journal & Year:

J Natl Compr Canc Netw | 2023