Alexander Stegh, PhD

Research Program Solid Tumor Therapeutics
Alexander Stegh

Researcher Background

Primary Academic Title

Professor of Neurological Surgery; Director of Research, Brain Tumor Center, WashU Medicine

Training

  • 2001 - 2002: Postdoctoral Fellow, University of Chicago, Chicago, IL
  • 2002 - 2007: Research Associate, Harvard University, Boston, MA

Education

  • 2000: PhD, Cell Biology, Biochemistry and Cancer Biology, University of Chicago, Chicago, IL

Research & Selected Publications

Research Interest

Pathogenesis of glioblastoma, mechanisms of tumor-mediated immune suppression, development of novel nanotechnology-enabled approaches directed against actionable immune targets

Research Publications

STING activation induces cytotoxic and immune responses in meningiomas via inflammatory cell death pathways.
Authors:

Youngblood MW, Tripathi S, Najem H, one or more additional authors omitted Stegh AH, one or more additional authors omitted Heimberger AB

Journal & Year:

Nat Commun • 2026

cGAS-agonistic spherical nucleic acids reprogram the glioblastoma immune microenvironment and promote antitumor immunity.
Authors:

Mahajan AS, Dussold C, Kim S, one or more additional authors omitted Stegh AH

Journal & Year:

Proc Natl Acad Sci USA • 2025

Redox Homeostasis and Beyond: The Role of Wild-Type Isocitrate Dehydrogenases for the Pathogenesis of Glioblastoma.
Authors:

Murnan KM, Horbinski C, Stegh AH

Journal & Year:

Antioxid Redox Signal • 2023