Carl DeSelm, MD, PhD

Radiation Oncologist

Carl DeSelm

Appointment Options

Whether you’re seeking a new patient appointment or exploring treatment options and looking for a second opinion, our Siteman care coordinators are ready to assist you.

My Locations

Center for Advanced Medicine

Center for Advanced Medicine

On WashU Medicine Campus
4921 Parkview Place, Saint Louis, MO 63110
Gary C. Werths Building at Siteman Cancer Center

Gary C. Werths Building at Siteman Cancer Center

On WashU Medicine Campus
4500 Forest Park Avenue, Saint Louis, MO 63108

Expertise & Training

Clinical Expertise

  • As a member of our pancreatic and liver cancer specialist teams, Dr. DeSelm cares for patients diagnosed with these cancers through treatment and recovery. He also specializes in metastases involving the liver.

Primary Academic Title

Associate Professor of Radiation Oncology, WashU Medicine

Training

  • 2012 - 2013: Intern, Internal Medicine, WashU Medicine, St. Louis, MO
  • 2013 - 2016: Resident, Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York City, NY
  • 2016 - 2017: Holman Research Fellow, CAR-T Cell Therapy, Memorial Sloan Kettering Cancer Center, New York City, NY
  • 2017 - 2018: Translational Research Fellow, Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York City, NY

Education

  • 2012: MD, WashU Medicine, St. Louis, MO
  • 2012: PhD, Molecular and Cellular Biology, WashU Medicine, St. Louis, MO

Research & Selected Publications

Research Interest

Immune therapy/cellular therapy, where a patient’s immune cells are harnessed to fight the tumor.

Research Publications

Preconditioning with Low-Dose Radiation Improves Antitumor Immunity and Survival in DC-Vaccinated Mice
Authors:

Kwon E, Namen S, Willoughby CJ, one or more additional authors omitted DeSelm CJ

Journal & Year:

Life (Basel) | 2025

Exploitable mechanisms of antibody and CAR mediated macrophage cytotoxicity
Authors:

Liu T, Zhang M, Farsh T, one or more additional authors omitted DeSelm CJ

Journal & Year:

Nat Commun | 2025

Prostate cancer immunotherapy: Improving clinical outcomes with a multi-pronged approach
Authors:

Sridaran D, Bradshaw E, DeSelm C, one or more additional authors omitted Mahajan NP

Journal & Year:

Cell Rep Med | 2023

Memory-like Differentiation, Tumor-Targeting mAbs, and Chimeric Antigen Receptors Enhance Natural Killer Cell Responses to Head and Neck Cancer
Authors:

Jacobs MT, Wong P, Zhou AY, one or more additional authors omitted DeSelm CJ, one or more additional authors omitted Fehniger TA

Journal & Year:

Clin Cancer Res | 2023

Intrinsic tumor resistance to CAR T cells is a dynamic transcriptional state that is exploitable with low-dose radiation
Authors:

Kim AB, Chou SY, Kang S, one or more additional authors omitted DeSelm CJ

Journal & Year:

Blood Adv | 2023