Christopher Maher, PhD

Medical School Department Internal Medicine
Research Program Solid Tumor Therapeutics
Christopher Maher

Researcher Background

Primary Academic Title

Professor of Medicine, Division of Oncology, Section of Molecular Oncology, WashU Medicine

Training

  • 2007 - 2007: Postdoctoral fellow, cancer genomics, University of Western Cape, Cape Town, South Africa
  • 2007 - 2009: Postdoctoral Fellow, Cancer Genomics, University of Michigan, Ann Arbor, MI

Education

  • 2004: MS, Stony Brook University/Cold Spring Harbor Laboratory, Stony Brook, NY
  • 2006: PhD, Stony Brook University/Cold Spring Harbor Laboratory, Stony Brook, NY

Research & Selected Publications

Research Interest

Translating genome-based knowledge through integrative analysis of high-throughput genomic technologies into the development of novel diagnostic, prognostic and therapeutic strategies in cancer. Developing novel computational approaches to elucidate “driver” mutations within common carcinomas that may be hidden by nonspecific aberrations that will subsequently be validated in preclinical models.

Research Publications

Integration of Short- and Long-Read RNA Sequencing Enables the Discovery of Circular RNAs.
Authors:

Swift SZ, Webster J, Mai H, one or more additional authors omitted Maher CA

Journal & Year:

Cancer Res • 2026

Methylation-based signature to distinguish indolent and aggressive prostate cancer.
Authors:

Liao M, Webster J, Ly A, Rozycki E, Maher CA

Journal & Year:

Biol Open • 2025

Genomic and Epigenomic Analysis of Plasma Cell-Free DNA Identifies Stemness Features Associated with Worse Survival in Lethal Prostate Cancer.
Authors:

Chauhan PS, Alahi I, Sinha S, one or more additional authors omitted Maher CA, Chaudhuri AA

Journal & Year:

Clin Cancer Res • 2025

Integrative analysis of ultra-deep RNA-seq reveals alternative promoter usage as a mechanism of activating oncogenic programmes during prostate cancer progression.
Authors:

Zhang M, Sjöström M, Cui X, one or more additional authors omitted Maher CA, one or more additional authors omitted Quigley DA

Journal & Year:

Nat Cell Biol • 2024

Single cell-transcriptomic analysis informs the lncRNA landscape in metastatic castration resistant prostate cancer.
Authors:

Saha D, Dang HX, Zhang M, one or more additional authors omitted Maher CA

Journal & Year:

NPJ Genom Med • 2024

Single-cell transcriptomics reveals long noncoding RNAs associated with tumor biology and the microenvironment in pancreatic cancer.
Authors:

Dang HX, Saha D, Jayasinghe R, one or more additional authors omitted Maher CA

Journal & Year:

NAR Cancer • 2023

INTEGRATE-Circ and INTEGRATE-Vis: unbiased detection and visualization of fusion-derived circular RNA.
Authors:

Webster J, Mai H, Ly A, Maher C

Journal & Year:

Bioinformatics • 2023

PACT: a pipeline for analysis of circulating tumor DNA.
Authors:

Webster J, Dang HX, Chauhan PS, one or more additional authors omitted Maher CA

Journal & Year:

Bioinformatics • 2023