Clifford Luke, PhD

Medical School Department Pediatrics
Research Program Mechanisms of Cancer Biology Program
Clifford Luke

Researcher Background

Primary Academic Title

Professor of Pediatrics, Division of Newborn Medicine, WashU Medicine

Training

  • 1998 - 2001: Postdoctoral Fellow, The Children's Hospital, Boston, MA
  • 1998 - 2001: Research Fellow, Pediatrics, Harvard Medical School, Boston, MA

Education

  • 1998: PhD, University of Surrey, Guildford, U.K.

Research & Selected Publications

Research Interest

The role of proteases and their inhibitors in lysosomal mediated cell death pathways, the role of lysosomal membrane permeability in tumor cells in response to radiation and chemotherapeutics and ways to exacerbate cell death in response to these stressors.

Research Publications

SCCA1/SERPINB3 suppresses antitumor immunity and blunts therapy-induced T cell responses via STAT-dependent chemokine production.
Authors:

Chen L, Shi V, Wang S, one or more additional authors omitted Luke CJ, one or more additional authors omitted Markovina S

Journal & Year:

J Clin Invest • 2023