David Gutmann, MD, PhD

Pediatric Neurologist

David Gutmann

Appointment Options

Whether you’re seeking a new patient appointment or exploring treatment options and looking for a second opinion, our Siteman care coordinators are ready to assist you.

My Locations

Siteman Kids at St. Louis Children’s Hospital

Siteman Kids at St. Louis Children’s Hospital

On WashU Medicine Campus
1 Children's Place, St. Louis, MO 63110

Expertise & Training

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David Gutmann, MD, PhD

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Washington University neurologist David Gutmann, MD, PhD, discusses what patients with inherited cancer syndromes can expect from their extended care team at Siteman Cancer Center.

Clinical Expertise

  • Inherited Cancer Syndromes

Primary Academic Title

Director, Neurofibromatosis Center; Donald O. Schnuck Family Chair and Professor of Neurology, WashU Medicine

Board Certification

  • 1992: American Board of Psychiatry and Neurology

Training

  • 1986 - 1990: Resident, Neurology, University of Pennsylvania, Philadelphia, PA
  • 1990 - 1993: Postdoctoral Fellow, Human Molecular Genetics, Howard Hughes Medical Institute and University of Michigan, Ann Arbor, MI

Education

  • 1980: MS, Human Genetics, University of Michigan, Ann Arbor, MI
  • 1984: PhD, Microbiology and Immunology, University of Michigan, Ann Arbor, MI
  • 1986: MD, University of Michigan, Ann Arbor, MI

Research & Select Publications

Research Interest

The molecular biology of nervous system tumors, including neurofibromatosis 1, neurofibromatosis 2 and tuberous sclerosis 2 tumor suppressor gene products.

Research Publications

Central Precocious Puberty and Optic Pathway Glioma in Children with Neurofibromatosis 1: Associations with Tumor Location, Vision, and Treatment
Authors:

Katz J, Hillis E, Garzon JP, one or more additional authors omitted Gutmann DH

Journal & Year:

J Pediatr | 2026

Nested pediatric low-grade glioma cerebral organoid avatars reveal glutamatergic neuron stromal growth dependency
Authors:

Xu E, Zhang C, Rodriguez FJ, one or more additional authors omitted Gutmann DH

Journal & Year:

Genes Dev | 2026

Nested ecosystems theory for conceptualizing brain tumors
Authors:

Forster LA, Gutmann DH

Journal & Year:

Dis Model Mech | 2026

Pan-cancer single cell transcriptomic clustering reveals heterogeneous CD8+ exhausted T cell populations with different immune checkpoint inhibitor responses
Authors:

Mu R, Barakat R, Gutmann DH

Journal & Year:

Oncoimmunology | 2025

Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth
Authors:

Anastasaki C, Mu R, Kernan CM, one or more additional authors omitted Gutmann DH

Journal & Year:

Neuron | 2025

Intestinal Bacteroides drives glioma progression by regulating CD8+ T cell tumor infiltration
Authors:

Chatterjee J, Qi X, Mu R, one or more additional authors omitted Gutmann DH

Journal & Year:

Neuro-oncology | 2025

IRX2 and NPTX1 differential regulation of β-catenin underlies MEK-mediated proliferation in human neuroglial cells
Authors:

Chen A, Wang H, Li X, Anastasaki C, Gutmann DH

Journal & Year:

Genes Dev | 2025

Cognition and behavior in neurofibromatosis type 1: report and perspective from the Cognition and Behavior in NF1 (CABIN) Task Force
Authors:

Gutmann DH, Anastasaki C, Gupta A, one or more additional authors omitted Yohay KH

Journal & Year:

Genes Dev | 2025

Precision preclinical modeling to advance cancer treatment
Authors:

Gutmann DH, Boehm JS, Karlsson EK, one or more additional authors omitted Snyder JC

Journal & Year:

J Natl Cancer Inst | 2025

Precocious Puberty in Children with Neurofibromatosis Type 1
Authors:

Katz J, Ratnam S, Listernick RH, Habiby RL, Gutmann DH

Journal & Year:

J Pediatr | 2025

Early Young Adult Death Underscores the Need for Adolescent and Young Adult Transition Programs in Neurofibromatosis Type 1
Authors:

Tarnawsky T, Oh IY, Hillis E, Gupta A, Gutmann DH

Journal & Year:

J Pediatr | 2025

Integrating priorities at the intersection of cancer and neuroscience
Authors:

Hwang WL, Perrault EN, Birbrair A, one or more additional authors omitted Gutmann DH, one or more additional authors omitted Amit M

Journal & Year:

Cancer Cell | 2025

Head-to-head preclinical treatment design prioritizes promising therapies for neurofibromatosis type 1 optic glioma clinical translation
Authors:

Eligator T, Chatterjee J, Yamada S, one or more additional authors omitted Gutmann DH

Journal & Year:

Neurooncol Adv | 2025

Maternal obesogenic diet operates at the tumor cell of origin to increase incidence and decrease latency of neurofibromatosis type 1 optic pathway glioma
Authors:

Chan A, Zhang K, Martin G, one or more additional authors omitted Gutmann DH, Brossier NM

Journal & Year:

Neuro-oncology | 2024

Human single cell RNA-sequencing reveals a targetable CD8+ exhausted T cell population that maintains mouse low-grade glioma growth
Authors:

Barakat R, Chatterjee J, Mu R, one or more additional authors omitted Gutmann DH

Journal & Year:

Nat Commun | 2024