Gary Patti, PhD

Medical School Department Chemistry
Research Program Mechanisms of Cancer Biology Program
Gary Patti

Researcher Background

Primary Academic Title

Professor of Chemistry and of Genetics and Medicine, Michael and Tana Powell Professor of Chemistry, WashU Medicine

Training

  • 2008 - 2011: NIH Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA

Education

  • 2008: PhD, Chemistry, WashU Medicine, St. Louis, MO

Research & Selected Publications

Research Interest

We are interested in using advanced metabolic technologies to quantitatively cancer metabolism.

Research Publications

Decoding cancer across scales with metabolomics.
Authors:

Rowles JL, Patti GJ

Journal & Year:

Nat Rev Cancer • 2026

Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers.
Authors:

Shi M, Patti GJ, Gunter MJ, one or more additional authors omitted Cao Y

Journal & Year:

Cell • 2026

Rapid quantitation of NAD+/NADH and NADPH/NADP+ with mass spectrometry by using calibration constants.
Authors:

Guo Q, Wang ML, Schwaiger-Haber M, one or more additional authors omitted Patti GJ

Journal & Year:

Redox Biol • 2026

Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis.
Authors:

Khan A, Yen FS, Unlu G, one or more additional authors omitted Patti GJ, Birsoy K

Journal & Year:

Cell Metab • 2025

Intestine-derived sorbitol drives steatotic liver disease in the absence of gut bacteria.
Authors:

Jackstadt MM, Fowle-Grider R, Song MG, one or more additional authors omitted Patti GJ

Journal & Year:

Sci Signal • 2025

Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer.
Authors:

Fowle-Grider R, Rowles JL, Shen I, one or more additional authors omitted Patti GJ

Journal & Year:

Nature • 2024

Metabolite signatures of chronological age, aging, survival, and longevity.
Authors:

Sebastiani P, Monti S, Lustgarten MS, one or more additional authors omitted Patti GJ

Journal & Year:

Cell Rep • 2024

Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism.
Authors:

Zhang Y, Higgins CB, Tica S, one or more additional authors omitted Patti G, one or more additional authors omitted DeBosch BJ

Journal & Year:

Cell Metab • 2024