Grant A. Challen, PhD

Medical School Department Internal Medicine
Research Program Hematopoietic Development & Malignancy
Grant A. Challen

Researcher Background

Primary Academic Title

Professor of Medicine, Division of Oncology, Section of Molecular Oncology, WashU Medicine

Training

  • 2006 - 2012: Postdoctoral Fellow, Hematopoietic Stem Cells, Baylor College of Medicine, Houston, TX

Education

  • 2006: PhD, Developmental Biology, University of Queensland, Brisbane, Australia

Research & Selected Publications

Research Interest

Determining the effect of DNA methylation mediated by the de novo DNA methyltransferase enzymes on hematopoietic stem cell functio

Research Publications

Comparison with Ezh2 reveals the PRC2-dependent functions of Jarid2 in hematopoietic stem Cell lineage commitment.
Authors:

Bjeije H, Han W, Lin S, one or more additional authors omitted Challen GA

Journal & Year:

Stem Cell Reports • 2026

Parallel Evolution of Leukemic Clones in Myeloproliferative Neoplasms.
Authors:

Parsons TM, Krishnan A, Raj IX, one or more additional authors omitted Challen G

Journal & Year:

Res Sq • 2025

JAK2 V617F Myeloproliferative Neoplasms Support Parallel Evolution of Independent Leukemic Clones.
Authors:

Parsons TM, Krishnan A, Raj IX, one or more additional authors omitted Challen GA

Journal & Year:

bioRxiv • 2025

JARID2 Inhibition Reprograms Human Hematopoietic Progenitor Cells To Enhance Bone Marrow Transplantation.
Authors:

Han W, Bjeije H, Celik H, one or more additional authors omitted Challen GA

Journal & Year:

bioRxiv • 2025

Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity.
Authors:

Xavier Raj I, Kyun Koh W, Harrison J, one or more additional authors omitted Challen GA

Journal & Year:

Cell Stem Cell • 2025

Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis.
Authors:

Krishnan A, Miles LA, Challen GA

Journal & Year:

Exp Hematol • 2025

Functional Comparison to Ezh2 Reveals PRC2-Independent Functions of Jarid2 in Hematopoietic Stem Cell Lineage Commitment.
Authors:

Bjeije H, Han W, Issa N, one or more additional authors omitted Challen GA

Journal & Year:

bioRxiv • 2025

Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis.
Authors:

Young KA, Hosseini M, Mistry JJ, one or more additional authors omitted Challen GA, one or more additional authors omitted Trowbridge JJ

Journal & Year:

Nat Commun • 2025