Obi Griffith, PhD

Medical School Department Internal Medicine
Research Program Solid Tumor Therapeutics
Obi Griffith

Researcher Background

Primary Academic Title

Professor of Medicine, Division of Oncology, WashU Medicine

Training

  • 2008 - 2010: Postdoctoral Fellow, Medical Genetics, British Columbia Cancer Agency, Canada’s Michael Smith Genome Sciences Centre, Vancouver, BC
  • 2010 - 2012: Postdoctoral Fellow, Cancer and DNA Damage, Lawrence Berkeley National Laboratory, Berkeley, CA

Education

  • 2008: PhD, medical genetics, University of British Columbia, Vancouver, British Columbia, Canada

Research & Selected Publications

Research Interest

My research interests are best described as cancer informatics and clinical statistics with emphasis on use of high-throughput sequencing data in breast cancer. I use computational methods for the identification of molecular markers at the DNA, RNA and protein level that are useful for diagnosis, prognosis or predicting therapeutic response. My research focuses on understanding how changes in the coding and regulatory sequences of DNA contribute to cancer development and progression.

Research Publications

Adjuvant personalized multivalent neoantigen DNA vaccination for MGMT unmethylated glioblastoma: a phase 1 trial.
Authors:

Garfinkle EAR, Perales-Linares R, Gimple RC, one or more additional authors omitted Griffith OL, one or more additional authors omitted Johanns TM

Journal & Year:

Nat Cancer • 2026

Whole Exome Sequencing of Feline Oral Squamous Cell Carcinoma Reveals Genomic Parallels With Human Head and Neck Squamous Cell Carcinoma.
Authors:

Chu S, Skidmore ZL, Warren W, one or more additional authors omitted Griffith OL

Journal & Year:

Vet Comp Oncol • 2026

Targeted deep sequencing identifies mosaicism in patients with immune dysregulation.
Authors:

Schmitz EG, Paul AJ, Ghosh R, one or more additional authors omitted Griffith OL, one or more additional authors omitted Cooper MA

Journal & Year:

J Allergy Clin Immunol • 2026

Searching the Druggable Genome using Large Language Models.
Authors:

Schimmelpfennig L, Cannon M, Cody Q, one or more additional authors omitted Griffith OL

Journal & Year:

bioRxiv • 2026

Integrating interferon gamma receptor pathways, antigenicity, and immune contexture as predictors of immunotherapeutic strategies for mucosal melanomas.
Authors:

Monti M, Picinoli S, Bozzola A, one or more additional authors omitted Griffith O, one or more additional authors omitted Vermi W

Journal & Year:

J Immunother Cancer • 2026

CIViC MCP: Integrating Large Language Models with the Clinical Interpretations of Variants in Cancer.
Authors:

Schimmelpfennig L, Cody Q, McMichael J, one or more additional authors omitted Griffith OL

Journal & Year:

bioRxiv • 2025

Large B cell lymphoma microenvironment archetype profiles.
Authors:

Li X, Singhal K, Deng Q, one or more additional authors omitted Griffith OL, one or more additional authors omitted Green MR

Journal & Year:

Cancer Cell • 2025

Identifying genetic errors of immunity due to mosaicism.
Authors:

Schmitz EG, Griffith M, Griffith OL, Cooper MA

Journal & Year:

J Exp Med • 2025