Mengcheng Shen, PhD

Research Program Prevention and Control, Solid Tumor Therapeutics
Mengcheng Shen

Researcher Background

Primary Academic Title

Assistant Professor of Medicine, WashU Medicine

Training

  • 2018 - 2023: Postdoctoral Researcher, Stanford, University, Stanford, CA
  • 2023 - 2025: Instructor, Stanford University, Stanford, CA

Education

  • 2009: BS, Nanjing Agricultural University, China
  • 2012: M.Sc., Nanjing Agricultural University, China
  • 2018: PhD, University of Alberta, Canada

Research & Selected Publications

Research Interest

My research in cardo-oncology focuses on leveraging patient-derived induced pluripotent stem cells (iPSCs) to generate cardiovascular cells. I employ high-throughput CRISPR screens to identify off-target mechanisms that contribute to cardiovascular toxicity associated with anti-cancer drugs. My ultimate goals is to develop personalized cancer therapies that minimize off-target cardiovascular effects, ensuring safer and more effective treatment options for patients.

Research Publications

Human Single-Nucleus RNA Sequencing Identifies CD47 as a Therapeutic Target for Doxorubicin-Induced Cardiomyopathy.
Authors:

Guo Z, Ataran A, Ma P, one or more additional authors omitted Shen M, one or more additional authors omitted Javaheri A

Journal & Year:

Circulation • 2025