Simon Goedegebuure, PhD

Medical School Department Surgery
Research Program Tumor Immunology
Simon Goedegebuure

Researcher Background

Primary Academic Title

Associate Professor of Surgery, Section of General Surgery, Division of Endocrine and Oncologic Surgery, WashU Medicine

Research & Selected Publications

Research Interest

Design of immune-based treatment for cancer, in particular breast and pancreas cancer. We currently focus on the design of tumor vaccines that induce T lymphocyte-mediated anti-tumor responses. At the same time, we try to better understand mechanisms of immune suppression in cancer patients with the goal to inhibit/overcome immune suppression. Our ultimate goal is to test a combination of vaccination and neutralization of immune suppression in cancer patients.

Research Publications

Adjuvant personalized multivalent neoantigen DNA vaccination for MGMT unmethylated glioblastoma: a phase 1 trial.
Authors:

Garfinkle EAR, Perales-Linares R, Gimple RC, one or more additional authors omitted Goedegebuure SP, one or more additional authors omitted Johanns TM

Journal & Year:

Nat Cancer • 2026

pVACview: an interactive visualization tool for efficient neoantigen prioritization and selection.
Authors:

Xia H, Hoang MH, Schmidt E, one or more additional authors omitted Goedegebuure SP, one or more additional authors omitted Griffith M

Journal & Year:

Genome Med • 2024

Neoantigen DNA vaccines are safe, feasible, and induce neoantigen-specific immune responses in triple-negative breast cancer patients.
Authors:

Zhang X, Goedegebuure SP, Chen MY, one or more additional authors omitted Gillanders WE

Journal & Year:

Genome Med • 2024

Tumour evolution and microenvironment interactions in 2D and 3D space.
Authors:

Mo CK, Liu J, Chen S, one or more additional authors omitted Goedegebuure SP, one or more additional authors omitted Ding L

Journal & Year:

Nature • 2024