Wayne Yokoyama, MD

Medical School Department Rheumatology
Yokoyama-Wayne

Researcher Background

Primary Academic Title

Sam J. Levin and Audrey Loew Levin Chair for Research of Arthritis; Professor of Medicine; and Chief, Division of Rheumatology, Washington University School of Medicine

Training

  • 1978 - 1981: Resident, internal medicine, University of Iowa, Iowa City, IA
  • 1981 - 1982: Clinical fellow, rheumatology, University of Iowa, Iowa City, IA
  • 1982 - 1985: Research fellow, rheumatology, University of Iowa, Iowa City, IA
  • 1985 - 1989: Research fellow, immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD

Education

  • 1978: MD, University of Hawaii, Honolulu, HI

Research & Selected Publications

Research Interest

Our current work is focused on determining the molecular basis for NK cell recognition of their tumor or infected targets and using this understanding to dissect the role of NK cells in tumor induction, viral infection and bone marrow transplantation in vitro and in vivo.

Shared pathway of WDFY4-dependent cross-presentation of immune complexes by cDC1 and cDC2.
Authors:

Jo S, Ohara RA, Theisen DJ, one or more additional authors omitted Yokoyama WM, one or more additional authors omitted Murphy KM

Journal & Year:

J Exp Med • 2025

Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions.
Authors:

Piersma SJ, Li S, Wong P, one or more additional authors omitted Yokoyama WM

Journal & Year:

Elife • 2025

Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions.
Authors:

Piersma SJ, Li S, Wong P, one or more additional authors omitted Yokoyama WM

Journal & Year:

bioRxiv • 2024

Cis-regulatory evolution of the recently expanded Ly49 gene family.
Authors:

Fan C, Xing X, Murphy SJH, one or more additional authors omitted Yokoyama WM, Wang T

Journal & Year:

Nat Commun • 2024

NK cell expansion requires HuR and mediates control of solid tumors and long-term virus infection.
Authors:

Piersma SJ, Bangru S, Yoon J, one or more additional authors omitted Yokoyama WM

Journal & Year:

J Exp Med • 2023

Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.
Authors:

Rožmanić C, Lisnić B, Pribanić Matešić M, one or more additional authors omitted Yokoyama WM, one or more additional authors omitted Brizić I

Journal & Year:

Nat Commun • 2023

Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDAC.
Authors:

Baer JM, Zuo C, Kang LI, one or more additional authors omitted Yokoyama WM, one or more additional authors omitted DeNardo DG

Journal & Year:

Nat Immunol • 2023