Gabriel Mbalaviele, PhD

Medical School Department Developmental Biology
Research Program Tumor Immunology
Gabriel Mbalaviele

Researcher Background

Primary Academic Title

Professor of Medicine, Division of Bone and Mineral Diseases, WashU Medicine

Training

  • 2007 - 2010: Associate Research Fellow, St. Louis, MO

Education

  • 1992: PhD, University of Pairs, Paris, France

Research & Selected Publications

Research Interest

Role of inflammasomes and gasdermins in pathophysiology.

Research Publications

Activation of the noncanonical inflammasome-GSDMD pathway triggers pyroptosis in bone marrow and promotes periosteal bone formation.
Authors:

Zou W, Wang C, Li Y, one or more additional authors omitted Mbalaviele G

Journal & Year:

J Bone Miner Res • 2026

Activation of the noncanonical inflammasome-GSDMD pathway triggers pyroptosis in bone marrow and promotes periosteal bone formation.
Authors:

Zou W, Wang C, Li Y, one or more additional authors omitted Mbalaviele G

Journal & Year:

bioRxiv • 2025

NLRP3 inflammasome is regulated in osteoclasts through a Tmem178-dependent mechanism that restricts calcium influx.
Authors:

Kaur K, Alippe Y, Wang C, one or more additional authors omitted Mbalaviele G

Journal & Year:

bioRxiv • 2025

Chemotherapy activates inflammasomes to cause inflammation-associated bone loss.
Authors:

Wang C, Kaur K, Xu C, Abu-Amer Y, Mbalaviele G

Journal & Year:

Elife • 2024

Tmem178 Negatively Regulates IL-1β Production Through Inhibition of the NLRP3 Inflammasome.
Authors:

Khanna K, Yan H, Mehra M, one or more additional authors omitted Mbalaviele G, one or more additional authors omitted Faccio R

Journal & Year:

Arthritis Rheumatol • 2024