Chun-Kan Chen, PhD

Chun-Kan Chen

Researcher Background

Primary Academic Title

Assistant Professor, Departments of Cell Biology and Physiology, WashU Medicine

Training

  • 2009 - 2010: Summer Internship Research Assistant Institute of Molecular Biology, Academia Sinica, Taiwan

Education

  • 2017: PhD, California Institute of Technology, Pasadena, CA

Research & Selected Publications

Research Interest

My research focuses on circular RNAs (circRNAs) and their contribution to cancer progression. The human genome encodes thousands of highly conserved circRNAs, with hundreds serving as protein synthesis templates. Disruption of protein-coding circRNAs has been associated with cancer, but the molecular mechanisms remain unclear. Utilizing high-throughput screening, next-generation sequencing, and mass spectrometry, I aim to reveal the roles of protein-coding circRNAs in cancer progression and uncover related mechanisms. Establishing links between circRNAs and cancer will offer insights into circRNA dysregulation, and help identify potential treatments targeting circRNA-encoded proteins, leading to more effective cancer therapy.

Research Publications

A phase I window-of-opportunity study of neoadjuvant avelumab and hypofractionated radiation therapy in radiation-relapsed meningioma.
Authors:

Huang J, Johanns TM, Campian JL, one or more additional authors omitted Chen CK

Journal & Year:

medRxiv • 2025

YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks.
Authors:

Tsao N, Lombardi PM, Park A, one or more additional authors omitted Chen CK, Mosammaparast N

Journal & Year:

Mol Cell • 2025