Lavinia Sheets, PhD

Medical School Department Otolaryngology
Research Program Prevention and Control
Lavinia Sheets

Researcher Background

Primary Academic Title

Associate Professor, Department of Otolaryngology - Head & Neck Surgery, WashU Medicine

Training

  • 2007 - 2013: Postdoctoral Research Associate, Molecular Basis of Hearing and Balance, Howard Hughes Medical Institute, Oregon Hearing Research Center and Collum Institute, Portland, OR
  • 2013 - 2015: Amelia Peabody Research Fellow, Independent Investigator, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA
  • 2015 - 2017: Instructor, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA

Education

  • 2007: PhD, Oregon Health & Science University, Portland, OR

Research & Selected Publications

Research Interest

Cisplatin is an effective and widely used antineoplastic drug. But it is also associated with toxic side effects, including neuropathy and permanent hearing loss. My research group has optimized a zebrafish model ototoxicity and neurotoxicity with the goal of uncovering therapeutic strategies to protect sensory hair cells and nerve fibers from damage during cisplatin-based chemotherapy.

Research Publications

Direct targeting of mitochondria by cisplatin leads to cytotoxicity in zebrafish lateral-line hair cells.
Authors:

Lee DS, Schrader A, Zou J, one or more additional authors omitted Sheets L

Journal & Year:

iScience • 2024

Cisplatin drives mitochondrial dysregulation in sensory hair cells.
Authors:

Lee DS, Schrader A, Zou J, one or more additional authors omitted Sheets L

Journal & Year:

bioRxiv • 2024