Advanced Physician Search: Metastatic/Recurrent

202504194

Brief Summary

The study is for patients with advanced melanoma who are eligible for standard therapy with Pembrolizumab.

Protocol Interventions

Drug: EIK1001, Drug: Pembrolizumab (KEYTRUDA® )

202407200

Brief Summary

This study is researching an experimental drug called fianlimab (also known as REGN3767), combined with another medication called cemiplimab (also known as REGN2810), called study drugs. The study is focused on patients with a type of skin cancer known as melanoma. The aim of the study is to see how safe and effective the combination of fianlimab and cemiplimab is in treating melanoma, in comparison with the combination of two medications, relatlimab and nivolumab, commercialized under the brand name Opdualag™ and approved for the treatment of melanoma in adults and children. The study is looking at several other research questions, including: * What side effects may happen from taking the study drugs. * How much study drug is in the blood at different times. * Whether the body makes antibodies against the study drugs (which could make the drug less effective or could lead to side effects)

Protocol Interventions

Drug: relatlimab+nivolumab

202404189

Brief Summary

This is a Phase 1 open-label, study designed to characterize the safety, tolerability, and preliminary anti-tumor activity of memory-like natural killer cells (ML NK) in combination with nivolumab and relatlimab in subjects with advanced and/or metastatic melanoma. There will be two arms to test the variables of ML NK cell source. ML NK cells from an autologous source will be used for Arm 1, and ML NK cells from an allogeneic source will be used for Arm 2. The investigators hypothesize that ML NK cells from either an autologous source or allogeneic source are safe and tolerable in subjects with advanced and/or metastatic melanoma.

Protocol Interventions

Biological: Cytokine-induced memory-like natural killer cells, Biological: Relatilmab, Biological: Nivolumab

202303101

Brief Summary

In this first-in human, phase I/IIa study, the safety and efficacy of [212Pb]VMT01, an alpha-particle emitting therapeutic agent targeted to melanocortin sub-type 1 receptor (MC1R) is being evaluated as a monotherapy and in combination with nivolumab in subjects with unresectable and metastatic melanoma.

Protocol Interventions

Drug: [203Pb]VMT01, Drug: [212Pb]VMT01, Drug: Nivolumab