Megan Cooper, MD, PhD

Medical School Department Pediatrics
Research Program Hematopoietic Development & Malignancy
Megan Cooper

Researcher Background

Primary Academic Title

Anthony R French Professor of Pediatrics, Division of Pediatric Rheumatology & Immunology, WashU Medicine

Training

  • 2004 - 2006: Resident, Pediatrics, WashU Medicine, St. Louis, MO
  • 2006 - 2007: Fellow, Pediatric Rheumatology, WashU Medicine, St. Louis, MO
  • 2007 - 2010: Research Fellow, Pediatric Rheumatology, WashU Medicine, St. Louis, MO

Education

  • 2002: PhD, Ohio State University, Columbus, OH
  • 2004: MD, Ohio State University, Columbus, OH

Research & Selected Publications

Research Interest

Natural killer cells, immune cells capable of targeting and killing cancer cells. Boosting the long-term response of natural killer cell memory by studying the fundamental mechanisms by which these cells can “remember.”

Research Publications

Multicenter international cohort study of haploinsufficiency of A20 reveals novel genetic architecture and phenotypic evolution.
Authors:

He T, Wang J, Carpio Tumba M, one or more additional authors omitted Cooper MA, one or more additional authors omitted Zhou Q

Journal & Year:

J Allergy Clin Immunol • 2026

Multiomic study of cutaneous T-cell lymphoma reveals single-cell clonal evolution in progression and therapy resistance.
Authors:

Dorando HK, Andrews JM, Khatavkar OU, one or more additional authors omitted Cooper MA, one or more additional authors omitted Payton JE

Journal & Year:

Blood • 2026

Targeted deep sequencing identifies mosaicism in patients with immune dysregulation.
Authors:

Schmitz EG, Paul AJ, Ghosh R, one or more additional authors omitted Cooper MA

Journal & Year:

J Allergy Clin Immunol • 2026

Clinical relevance of mosaic variants detected by exome sequencing.
Authors:

Ghosh R, Fazal Z, Oler AJ, one or more additional authors omitted Cooper MA, one or more additional authors omitted Walkiewicz MA

Journal & Year:

J Allergy Clin Immunol • 2026

Clinical characteristics, management, and hematopoietic cell transplantation of patients with TLR8 gain-of-function.
Authors:

Arnold DE, Kaviany S, Aluri J, one or more additional authors omitted Cooper MA

Journal & Year:

Blood Adv • 2026

ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation.
Authors:

Sohn H, Kolicheski A, Poursine-Laurent J, one or more additional authors omitted Cooper MA

Journal & Year:

J Immunol • 2025

Mosaic STAT5B gain-of-function associated with demyelinating disease and autoimmunity.
Authors:

Schmitt EG, Saucier N, Risma SI, one or more additional authors omitted Cooper MA

Journal & Year:

J Hum Immun • 2025

Rheumatologic and Autoimmune Features of Inborn Errors of Immunity: Implications for Diagnosis and Management.
Authors:

Tobin JM, Cooper MA

Journal & Year:

J Hum Immun • 2025