Stephen Sykes, PhD

Research Program Hematopoietic Development & Malignancy
Stephen Sykes

Researcher Background

Primary Academic Title

Associate Professor of Pediatrics, Division of Hematology/Oncology, WashU Medicine

Training

  • 2008 - 2009: Postdoctoral Fellow, Hematology, Brigham & Women's Hospital, Boston, MA
  • 2009 - 2012: Postdoctoral fellow, Regenerative Medicine, Massachusetts General Hospital, Boston, MA

Education

  • 2007: PhD, Cellular and Molecular Biology, University of Pennsylvania, Philadelphia, PA

Research & Selected Publications

Research Interest

Identifying and defining those molecular features that drive leukemogenesis and then use that information to develop rational therapeutic strategies for improving outcomes in acute leukemia

Research Publications

Reprogramming of Fatty Acid Metabolism in Acute Leukemia.
Authors:

Sokei J, Kanefsky J, Sykes SM

Journal & Year:

J Cell Physiol • 2025

Missense Mutations in Myc Box I Influence Nucleocytoplasmic Transport to Promote Leukemogenesis.
Authors:

Arthur NBJ, Christensen KA, Mannino K, one or more additional authors omitted Sykes SM, Ferraro F

Journal & Year:

Clin Cancer Res • 2024

Disruption of polyunsaturated fatty acid biosynthesis drives STING-dependent acute myeloid leukemia cell maturation and death.
Authors:

Kanefsky J, Basse M, Sokei J, one or more additional authors omitted Sykes SM

Journal & Year:

J Biol Chem • 2024

Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms.
Authors:

He F, Laranjeira AB, Kong T, one or more additional authors omitted Sykes SM, one or more additional authors omitted Oh ST

Journal & Year:

J Clin Invest • 2024