Dennis Goldfarb, PhD

Research Program Mechanisms of Cancer Biology Program
Dennis Goldfarb

Researcher Background

Primary Academic Title

Assistant Professor, Department of Cell Biology and Physiology, WashU Medicine

Training

  • 2018 - 2019: Postdoctoral Research Associate, Mass Spectrometry and Proteomics, University of North Carolina, Chapel Hill, NC

Education

  • 2018: PhD, Computer Science, University of North Carolina, Chapel Hill, NC

Research & Selected Publications

Research Interest

Understanding mechanisms in cellular biology and disease; using machine learning, statistical modeling and computer science to improve protein identification/quantification and to create novel analytical capabilities.

Research Publications

Post-translational modification of H2B C-terminal helix regulates nucleosome interactions and chromatin signaling.
Authors:

Zhao Y, Nguyen A, Arteaga EC, one or more additional authors omitted Goldfarb D, McGinty RK

Journal & Year:

Nucleic Acids Res • 2025

APC/C-mediated ubiquitylation of extranucleosomal histone complexes lacking canonical degrons.
Authors:

Skrajna A, Bodrug T, Martinez-Chacin RC, one or more additional authors omitted Goldfarb D, one or more additional authors omitted McGinty RK

Journal & Year:

Nat Commun • 2025

Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency.
Authors:

Chen J, Su S, Pickar-Oliver A, one or more additional authors omitted Goldfarb D, one or more additional authors omitted Liu P

Journal & Year:

Nucleic Acids Res • 2024