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Research & Selected Publications

Serendipitous discovery of an allosteric inhibitor binding groove in the proline biosynthetic enzyme pyrroline-5-carboxylate reductase 1
Authors:

Meeks KR, Mattingly CJ, Nix JC, one or more additional authors omitted Tanner JJ

Journal & Year:

Biochem J | 2026

Visualization of covalent intermediates and conformational states of proline utilization A by X-ray crystallography and molecular dynamics simulations
Authors:

Buckley DP, Becker DF, Tanner JJ

Journal & Year:

J Biol Chem | 2025

Biochemical, structural, and cellular characterization of S-but-3-yn-2-ylglycine as a mechanism-based covalent inactivator of the flavoenzyme proline dehydrogenase
Authors:

Meeks KR, Ji J, Scott GK, one or more additional authors omitted Tanner JJ

Journal & Year:

Arch Biochem Biophys | 2025

Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenas…
Authors:

Meeks KR, Bogner AN, Nix JC, Tanner JJ

Journal & Year:

Molecules | 2024

Noncovalent Inhibition and Covalent Inactivation of Proline Dehydrogenase by Analogs of N-Propargylglycine
Authors:

Tanner JJ, Ji J, Bogner AN, one or more additional authors omitted Becker DF

Journal & Year:

Biochemistry | 2024

Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)
Authors:

Meeks KR, Bogner AN, Tanner JJ

Journal & Year:

Protein Sci | 2024

Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography
Authors:

Meeks KR, Ji J, Protopopov MV, one or more additional authors omitted Tanner JJ

Journal & Year:

J Chem Inf Model | 2024