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Research & Selected Publications

Pyrimethamine and a potent analog inhibit NRF2 by suppressing one-carbon metabolism
Authors:

Chembo J, Bowman BM, Lapak K, one or more additional authors omitted Major MB

Journal & Year:

J Biol Chem | 2025

Pyrimethamine and a potent analogue WCDD115 inhibit NRF2 by suppressing DHFR and one-carbon metabolism
Authors:

Chembo J, Bowman BM, Lapak K, one or more additional authors omitted Major MB

Journal & Year:

bioRxiv | 2025

Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasia
Authors:

Paiboonrungruang C, Xiong Z, Lamson D, one or more additional authors omitted Chembo J, one or more additional authors omitted Chen X

Journal & Year:

Redox Biol | 2023