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Core Leadership Council
Director
Alessandro Vindigni, PhD
Our laboratory focuses on DNA replication and repair, and the roles of these pathways on cancer initiation, progression and response to chemotherapy and immunotherapy. We utilize a unique combination of biochemical, cellular, and electron microscopy approaches to study replication perturbations at single molecule resolutions.
Core Leadership Council:
Mary Mullen, MD
Our lab focuses on uncovering mechanisms of chemotherapy resistance in gynecologic cancers by integrating patient-derived models, DNA damage repair biology, and translational research to develop novel biomarkers and therapeutic strategies.
Abby Green, MD
Our lab uses molecular and cell biology, biochemistry, genome sequencing, proteomics, and animal models to evaluate mechanisms of mutagenesis and the subsequent impact on oncogenesis and tumor evolution.
Nima Mosammaparast, MD, PhD
The focus of genomic integrity has naturally been on how DNA is replicated and repaired. While most of the machinery that performs these functions are well-understood, how the cell “knows” which repair pathway to activate when it encounters a specific form of DNA damage is quite unexplored.
Priyanka Verma, PhD
Work in the Verma lab focuses on understanding the cause and consequences of DNA damage in cancer cells.
John Krais, PhD
In the Krais lab’s recent work, we are studying how genetic or pharmacologic inactivation of DNA damage repair pathways can trigger a dependence on alternative repair mechanisms.
